Italy bring in Guglielmo Vicario and Manuel Locatelli for the final Nations League group game against France’s Marcus Thuram, Christopher Nkunku and Manu Koné.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the Liveblog.
While both teams have already booked their spot in the quarter-finals of the competition, winning the group would secure top seed status in the draw.
The Azzurri need only a point to get that result, although even a defeat by one clear goal could suffice over goal difference.
Luciano Spalletti’s side won every game in this group except for the 2-2 draw against Belgium when down to 10 men.
That includes the comeback 3-1 victory in Paris back in September.
There was a last-minute change, as Gianluigi Donnarumma was all set to be the captain of Italy until he suffered from a stomach bug and is replaced by Tottenham Hotspur goalkeeper Vicario for his fourth cap.
Monza player Daniel Maldini and Fiorentina striker Moise Kean had been tipped to come in, but instead Nicolò Barella retains his trequartista role.
The only real difference therefore is Manuel Locatelli replacing Nicolo’ Rovella in midfield.
Riccardo Calafiori, Samuele Ricci and Lorenzo Pellegrini are among those out injured.
France do not start Milan left-back Theo Hernandez due to a knee issue, while Eduardo Camavinga is suspended following his yellow card in the 0-0 draw with Israel on Thursday.
Others who missed out include Aurelien Tchaouameni, Ousmane Dembele and Wesley Fofana.
Didier Deschamps shifts to a 4-3-3 formation rather than 4-2-3-1, using Inter striker Thuram and bringing Lazio midfielder Matteo Guendouzi into the starting XI.
Italy vs. France line-ups
Italy: Vicario; Di Lorenzo, Buongiorno, Bastoni; Cambiaso, Frattesi, Locatelli, Tonali, Dimarco; Barella; Retegui
Italy bench: Donnarumma, Meret, Savona, Gatti, Maldini, Raspadori, Kean, Rovella, Okoli, Comuzzo, Udogie, Pisilli
France: Maignan; Koundé, Konaté, Saliba, Digne; Koné, Rabiot, Guendouzi; Kolo Muani, M Thuram, Nkunku
France bench: Samba, Chevalier, Pavard, Upamecano, Olise, Coman, Kanté, Zaire-Emery, Barcola, Theo Hernandez
Ref: Vincic (SVN)
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Nations League Liveblog: Italy vs. France