The Reds skipper again started alongside January arrival Ozan Kabak at centre-back, with Jurgen Klopp’s defence breached inside three minutes after James Rodriguez teed up Richarlison for an early opener.
If that wasn’t enough of a first-half setback for Liverpool, looking to avoid a fourth straight home league defeat, they then lost their captain to injury on the 30-minute mark.
Henderson went down with what looked like a painful groin injury at Anfield and appeared a certainty to be heading off, but was obviously desperate to continue as he tried to stretch off the issue and re-entered the field of play.
However, that return was to prove very short-lived as Henderson was quickly replaced by Nat Phillips.
It is the latest potentially costly injury to an important Liverpool player sustained in the Merseyside derby this term.
In October’s 1-1 draw at Goodison Park, the club’s defensive talisman Virgil van Dijk suffered a serious knee ligament injury following a wild challenge by Everton goalkeeper Jordan Pickford and ended up needing surgery that is set to keep him out for the remainder of the 2020/21 campaign.
That match will no doubt be looked back upon as an important moment in the collapse of Liverpool’s top-flight title defence and it also signalled the start of a defensive injury crisis that has blighted the Reds all season and forced Klopp to deploy multiple different centre-back combinations.
Liverpool are also without Joel Matip and Joe Gomez for the rest of the season, with Kabak and Ben Davies arriving in January in order to ease that particular issue.